Brand Name	:	Roxilab Plus 250mg, 500mg, 70ml GFS
Generic Name	:	Cefuroxim + Clavulanic Acid
Price	:	BDT: 25.00
Therapeutic Class	:	Antibiotic Products
Section	:	Antibiotics
Dosages	:	Adult: 250/500mg tablet every 12 hourly Or 20-30 mg /Kg/Day, Child over 3 month: 20-30mg /kg/day
Indication	:	SSTI, RTI, UTI, Typhoid fever, Pharyngitis/Tonsillitis, Acute Bacterial Otitis Media, Acute Bacterial Maxillary Sinusitis, Acute Bacterial Exacerbations of Chronic Bronchitis,

Product Details

Composition:

Roxilab Plus 250 Tablet : Each film coated tablet contains Cefuroxime 250 mg as Cefuroxime Axetil BP and Clavulanic Acid 62.5 mg as Potassium Clavulanate BP.

Roxilab Plus 500 Tablet : Each film coated tablet contains Cefuroxime 500 mg as Cefuroxime Axetil BP and Clavulanic Acid 125 mg as Potassium Clavulanate BP.

Roxilab Plus 70 ml GFS: Each GFS 5ml contains Cefuroxime 125 mg as Cefuroxime Axetil BP and Clavulanic Acid 31.5 mg as Potassium Clavulanate BP.

Description:

Cefuroxime is a broad spectrum second generation Cephalosporin active against a wide range of Gram-positive and Gram-negative susceptible organisms including many beta-lactamase producing strains. The bactericidal action of Cefuroxime results from inhibition of cell wall synthesis by binding to essential target proteins. Cefuroxime has good stability to bacterial beta-lactamases.

Clavulanic Acid has a similar structure to the beta-lactam antibiotics but binds irreversibly to the beta-lactamase enzymes. The presence of Clavulanic Acid protects Cefuroxime from degradation by beta-lactamase enzymes and effectively extends the antibacterial spectrum of Cefuroxime to include many bacteria normally resistant to Cefuroxime and other Cephalosporins.

Side Effects:

Generally Cefuroxime-Clavulanic Acid is well tolerated. Major adverse reactions which may occur are diarrhea, nausea, vomiting, transient elevation in AST, ALT, LDH and eosinophilia. Other adverse events that may occur are abdominal pain, abdominal cramps, flatulence, indigestion, headache, vaginitis, rash, itch, dysuria, sleepiness, thirst, anorexia etc.

Pregnancy &Lactation : All antibiotics should be avoided in the first trimester if possible. However, Cefuroxime-Clavulanic Acid can be safely used in later pregnancy to treat Urinary Tract and other infections. Cefuroxime-Clavulanic Acid is excreted into the breast milk in small quantities and consequently caution should be exercised when it is administered to a nursing mother.

Contraindication:

Cefuroxime-Clavulanic Acid is contraindicated in patients with known allergy to Cephalosporins& in patients with Pseudomonas Colitis.

Precautions:

As with other broad-spectrum antibiotics, prolonged administration of Cefuroxime and Clavulanic Acid combination may result in overgrowth of non-susceptible microorganisms.

Drug Interaction :

Concomitant administration of Probenecid with Cefuroxime-Clavulanic Acid increases the area under the serum concentration versus time curve by 50%. Drug that reduces gastric acidity may result in a lower bioavailability of Cefuroxime and tend to cancel the effect of postprandial absorption.

Storage :

Keep away from light & moisture and store below 250 C temperature. Keep out of reach of children.