Brand Name	:	Gaba-aid 25mg, 50mg, 75mg
Generic Name	:	Gabapentin
Price	:	BDT: 12.00
Therapeutic Class	:	Vitamin & Mineral Products
Section	:	Vitamin & Mineral
Dosages	:	Neuropathic pain associated with diabetic peripheral neuropathy: The maximum recommended dose of Pregabalin is 100 mg three times a day (300 mg/day) in patients with creatinine clearance of at least 60 mL/min. Dosing should begin at 50 mg three times a da
Indication	:	Pregabalin is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy and management of post-herpetic neuralgia. It is also indicated for the adjunctive therapy for adult patients with partial onset seizures. It can

Product Details

Composition :
Gaba-Aid 25 Capsule : Each capsule contains Pregabalin INN 25 mg.

Gaba-Aid 50 Capsule : Each capsule contains Pregabalin INN 50 mg.

Gaba-Aid 75 Capsule : Each capsule contains Pregabalin INN 75 mg.

Description :
Pregabalin is a structural derivative of the inhibitory neurotransmitter gamma-amino butyric acid (GABA). It does not bind directly to GABA A, GABA B, or benzodiazepine receptor. It is inactive at serotonin & dopamine receptors and does not inhibit dopamine, serotonin or noradrenaline reuptake. It binds with high affinity to the alpha-2-delta site in central nervous system tissues. Pregabalin oral bioavailability is 90% and is independent of dose. It is eliminated from the systemic circulation primarily by renal excretion as unchanged drug with a mean elimination half-life of 6.3 hours in subjects with normal renal function.

Side Effects :
The most common side effects include dizziness, somnolence, dry mouth, edema, blurred vision, weight gain and abnormal thinking.
Pregnancy: Pregnancy category C. So it should only be used if potential benefit justifies the potential risks  to the fetus.
Lactation: It is not known if Pregabalin is excreted in human milk; it is, however, present in the milk  of rats. So it should be used in nursing mother only if there is a clear benefit over the risk.
Paediatric Use : The safety and efficacy of Pregabalin in paediatric patients have not been established.

Contraindication :
Pregabalin is contraindicated in patients with known hypersensitivity to Pregabalin or any of its components.

Precautions :

Discontinuation of Pregabalin without tapering may produce insomnia, nausea, headache  and diarrhea. So it should be tapered gradually over a minimum of 1 week rather than discontinued  abruptly. Creatinine kinase may be elevated if treated with Pregabalin. It should be discontinued rapidly if myopathy is diagnosed or suspected or if creatinine kinase is elevated markedly.

Drug Interaction :
There are no significant interactions between Pregabalin and other antiepileptic drugs like Carbamazepine, Valproic acid, Lamotrigine, Phenytoin, Phenobarbital, and Topiramate. Co-administration of Pregabalin with the oral contraceptives like norethisterone and ethinyl oestradiol does not influence the steady state pharmacokinetics of either agent. Pregabalin may potentiate the effets of Ethanol and Lorazepam.

Storage :
Keep away from light and store below 30o C. Keep out of the reach of children.