Brand Name	:	Rupa-aid 10 mg
Generic Name	:	Rupatidin
Price	:	BDT: 12.00
Therapeutic Class	:	Others
Section	:	Other
Dosages	:	Adults and adolescents (above 12 years) - The recommended dosage is 10 mg once daily, with or without food.
Indication	:	Rupatadine is indicated for the symptomatic treatment of Seasonal & Perennial Allergic Rhinitis and Urticaria.

Product Details

Description :

Rupatadine is a long-acting, non-sedative antagonist of histamine H1-receptors. It also antagonizes the platelet-activating factor (PAF). Both histamine and PAF cause bronchoconstriction which leads to an increase in the vascular permeability and act as a mediator in the inflammatory process. With the dual mode of action, Rupatadine shows better therapeutic effect than an isolated antihistamine. Rupatadine possesses other anti-allergic properties such as the inhibition of the degranulation of mast cells induced by immunological and non-immunological stimuli and inhibition of the release of cytokines, particularly of the tumor necrosis factor alpha (TNF a) in human mastocytes and monocytes.

Side Effect :

Sleepiness, headache, dizziness, dry mouth, fatigue, asthenia.

Use in Pregnancy &Lactation :

No adequate data available. Caution should be exercised when prescribing Rupatadine to pregnant or lactating women; it is unknown whether Rupatadine is excreted into breast milk.

Contraindications :

Hypersensitivity to Rupatadine or to any of the excipients.

Precautions :

Rupatadine should be used with caution in patients with known prolongation of the QT interval, patients with uncorrected hypokalemia, patients with ongoing proarrhythmic conditions, such as clinically significant bradycardia or acute myocardial ischemia. Rupatadine should be used with caution in elderly patients (65 years and older) due to little clinical data. As there is no clinical experience in patients with impaired kidney or liver function, the use of Rupatadine tablets is at present not recommended in these patients.

Drug Interaction :

The concomitant administration of Rupatadine and Ketoconazole or Erythromycin increases the systemic exposure. Rupatadine should be used with caution when it is coadministered with statins or CNS depressants or alcohol.

Storage :

Keep away from light, moisture and store below 30o C. Keep out of reach of children.